Cefuroxime axetil oral is hydrolyzed in the intestinal mucosa and blood to cefuroxime. Tablets contain the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, hydrogenated vegetable oil, hypromellose, microcrystalline. May 11, 2018 cefuroxime axetil should be avoided in patients with previous allergic reactions to cefuroxime, cephalosporin, penicillin, or other drugs. Reduce dosage by 50% if crcl is 1030 mlmin and by 75% if crcl. Ceftin cefuroxime axetil side effects, images, uses. Includes dosages for bacterial infection, urinary tract infection, bronchitis and more. Ceftin is available as a generic drug and is prescribed to treat infections with susceptible bacteria including skin and middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia, urinary tract infections, and gonorrhea.
Multiple dose dosing regimens with 7 to 10 days duration. In numerous randomised, controlled trials, 5 to 10 days treatment with oral cefuroxime axetil 250 or 500mg twice daily was an. Analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. If you get a rash, itchy skin, hives, difficulty breathing, or swelling of your face or mouth while taking ceftin cefuroxime axetil, talk to your doctor or go to the emergency room right away. Detailed cefuroxime dosage information for adults and children. Ceftin is a semisynthetic, broadspectrum cephalosporin antibiotic for oral administration. Reducing the dosage of cefuroxime axetil is recommended for adult patients with severe renal impairment creatinine clearance dosage and administration 2. Use with caution in patients with history of penicillin allergy. Acute sinusitis in the adult the study by freche et al. Chemically, cefuroxime axetil, the 1acetyloxy ethyl ester of cefuroxime, is rs 1. In clinical trials using a single 1,000 mg dose of cefuroxime axetil, 1,061 subjects were treated for uncomplicated gonorrhea.
Cefuroxime dosage in renal failure annals of internal. Cefuroxime axetil information, side effects, warnings and. Although rare, ceftin cefuroxime axetil can cause a severe and lifethreatening allergic reaction. For the treatment of bacterial infections, the recommended dose of cefuroxime axetil will vary, based on the type of infection being treated, other medical conditions you have, and other factors. General renal dosing guidelines agents not listed below click here for a specialized list of other renal medication dosing not listed in the alphabetical main section simple renal dosing guidelines. The recommended dose for mycobacterial infections in adults is 500 mg b. If experienced, these tend to have a severe expression. Cefuroxime axetil c20h22n4o10s cid 5361467 structure, chemical. In multipledose clinical trials, 912 subjects were treated with cefuroxime axetil 125 to 500 mg twice daily. Antibiotic renal dosing list with the age of antibiotic scrutiny upon us and cms starting to put antibiotics under the microscope, remedi seniorcare is happy to provide you with this antibiotic renal dosing list to. Dosing information the dose that your healthcare provider recommends will vary, depending on a number of factors, including. Penicillinase and nonpenicillinaseproducing strains of staphylococcus aureus. Cefuroxime axetil is in the amorphous form and has the following structural formula.
Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. Dosage in patients with impaired renal function a dosage interval adjustment is required for patients whose creatinine clearance is less than 30 mlmin, as listed in table 4 below, because cefuroxime is eliminated primarily by the kidney see clinical pharmacology 12. It was patented in 1976 and approved for medical use in 1987. The authors make no claims of the accuracy of the information contained herein. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Cefuroxime axetil is a second generation semisynthetic cephalosporin and a betalactam antibiotic with bactericidal activity.
Clarithromycin therapy should continue for life if clinical and mycobacterial improvements are observed. The activity depends on in vivo hydrolysis and release of cefuroxime tablets. Cefuroxime axetil indications, dose, side effects, brands. Ceftin cefuroxime axetil dose, indications, adverse. David greenwood, in antibiotic and chemotherapy ninth edition, 2010. The renal drug handbook the st georges hospital, adult critical. No unchanged ester is detectable in the systemic circulation. Cefuroxime axetil suspension for reconstitution side effects. Cefuroxime ceftin is an oral drug used to treat bacterial infections. Ceftibuten, ceftizoxime, ceftriaxone, cefuroxime axetil, cefuroxime sodium, celiprolol, cephalexin, cephradine, cetirizine, chlorambucil, chloramphenicol. Material safety data sheet material cefuroxime axetil tablets, usp 250 mg or 500 mg manufacturer lupin limited mumbai 400 098 india distributor lupin pharmaceuticals, inc. Common oral antimicrobial therapy dosage adjustments for renal function page 1 of 2. Learn about drug imprint, side effects, uses treating, dosage, interaction, overdose, and warnings.
Administer ceftin tablets or ceftin for oral suspension as described. Ceftin tablets and ceftin for oral suspension are not bioequivalent and are therefore not substitutable on a milligrampermilligram basis see clinical pharmacology 12. C1cr cefuroxime axetil in bioracef tablets was studied by means of long term 298 k60% rh, intermediate 303 k65% rh, accelerated 3 k75% rh and stress stability tests. Because cefuroxime is renally excreted, the serum halflife is prolonged in patients with. Pharmacokinetics and bactericidal activity of cefuroxime. The dose of cefuroxime axetil is 250 mg twice daily for 7. Tablets multipledose dosing regimens with 7 to 10 days duration. It will not work for colds, flu, or other viral infections. Side effects of ceftin cefuroxime axetil, warnings, uses. Until further data are available, the renal pharmacokinetic properties of cefuroxime axetil established in adults should not be extrapolated to pediatric patients. Cefuroxime axetil oral is hydrolyzed in the intestinal mucosa and. Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, has proven in vitro antibacterial activity against several grampositive and gramnegative organisms, including those most frequently associated with various common communityacquired infections.
Learn about side effects, warnings, dosage, and more. Your prescription label tells you how much to take at each dose. There are no adequate reports or wellcontrolled studies of cefuroxime in pregnant women. Ceftin oral dose range in adults is from 125mg to 500mg twice daily for 710 days and dosage in children is usually weight based. Usual dose every 24 hourscrcl less than 10 mlmin without hemodialysis. To reduce the development of drugresistant bacteria and maintain the effectiveness of cefuroxime axetil tablets and other antibacterial drugs, cefuroxime axetil tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. General dosing, susceptible infection red book aap 2015. Ceftin tablets and ceftin for oral suspension contain cefuroxime as cefuroxime axetil. It is best to take cefuroxime with food or milk, so try to take it at meal or snack times 12 hours apart. Let your doctor know of any allergies to antibiotics.
In multiple dose clinical trials, 912 subjects were treated with cefuroxime axetil 125 to 500 mg twice daily. Important administration instructions ceftin tablets and ceftin for oral suspension are not bioequivalent and are therefore not substitutable on a milligrampermilligram basis see clinical pharmacology 12. For patients with an estimated glomerular filtration rate of less than 10 mlmin, bennett and colleagues recommend 5%10% of the usual intravenous cefuroxime dosage. Cefuroxime is a secondgeneration cephalosporin antibiotic available in the form of oral tablets, capsules, and suspension as well as in intravenous formulation for the treatment of the following infections treatment of bone and joint infections caused by. Cefuroxime axetil could be used in patients with pneumonia and nontype 1 hypersensitivity reaction to. Ceftin cefuroxime axetil tablets, for oral use ceftin cefuroxime axetil, for oral suspension initial u. It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally. In clinical trials using a single 1,000mg dose of cefuroxime axetil tablets, 1,061 subjects were treated for uncomplicated gonorrhea. Cefuroxime drug monograph pediatric care online aap pointof.
Practice guidelines for the treatment of lyme disease. Therefore, as with all such antibiotics, in patients with markedly impaired renal function i. It is active against a wide range of grampositive and gram. Administration of macrolide antibiotics is not recommended as firstline therapy for early lyme disease ei. The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food. It is used to treat certain kinds of bacterial infections. Cefuroxime axetil is a semisynthetic analog of cephalosporin, a second generation cephalosporin and a prodrug of cefuroxime 16. There were no deaths or permanent disabilities thought related to drug toxicity in these studies. The level of renal function below which the dose of a drug must be reduced depends largely on the extent of renal metabolism and elimination, and on the drugs.
In this case it is important to treat the infection aggressively for the first 24hrs and recheck renal function before reducing the dose accordingly. The bioavailability of cefuroxime axetil was significantly enhanced in children by the concomitant ingestion of cefuroxime axetil and infant formula or whole milk. Dosing recommendations for children are in the table above. Pediatric patients aged years and older who cannot swallow the cefuroxime axetil tablets whole should receive cefuroxime axetil for oral suspension because the tablet has a strong, persistent bitter taste when crushed see dosage and administration 2. Peak serum levels of cefuroxime after administration of cefuroxime axetil occur within 2 to 3 hours following an oral dose. This third edition of the renal drug handbook is a fantastic publication. Since both the 250mg and 500mg tablets of augmentin contain the same amount of clavulanic acid 125 mg, as the potassium salt, two 250mg tablets of augmentin are not equivalent to one 500mg tablet of augmentin. This medication is known as a cephalosporin antibiotic. Ceftin fda prescribing information, side effects and uses. Cefuroxime axetil tablets usp are filmcoated and contain the equivalent of 250 mg or 500 mg of cefuroxime as cefuroxime axetil usp. May 17, 2019 detailed cefuroxime dosage information for adults and children. Safety and efficacy of oral cefuroxime in patients with renal impairment not established. Cefuroxime axetil versus ofloxacin for shortterm therapy of acute uncomplicated lower urinary tract infections in women.
Single dose cefuroxime axetil versus multiple dose cefaclor in the treatment of acute urinary tract infections. Will you have high blood pressure with cefuroxime axetil. Ceftin cefuroxime axetil tablets contain the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, hydrogenated vegetable oil, hypromellose, methylparaben, microcrystalline cellulose, propylene glycol, propylparaben, sodium benzoate, sodium. Use with caution in patients with renal impairment. When used, they should be reserved for patients who are intolerant of amoxicillin, doxycycline, and cefuroxime axetil table 4. Cefuroxime axetil is rapidly hydrolyzed in the intestinal mucosa, with approximately 37% of an oral dose reaching the systemic circulation as cefuroxime. This excellent reference provides dosage recommendations for various drugs when prescribed for patients with differing degrees of renal dysfunction.
Cefuroxime axetil tablets usp contain the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, hydrogenated vegetable oil, hypromellose, microcrystalline cellulose, polyethylene glycol, sodium. Aspartame present in cefuroxime axetil suspension is a source of phenylalanine and therefore it should not be used in patients suffering from phenylketonuria. Pharmacokinetics and bactericidal activity of cefuroxime axetil. Cefuroxime s effect is dependent on its binding to penicillinbinding proteins pbps located in the bacterial cytoplasmic membrane. Drug interactions with ceftin include vaccines for example, typhoid vaccine and probenecid. Ceftizoxime, ceftriaxone, cefuroxime axetil, cefuroxime sodium, cephalexin, cephradine, cetirizine, chlorothiazide, cidofovir, ciprofloxacin, cisatracurium. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions or encephalopathy. Cefuroxime axetil an overview sciencedirect topics. Cefuroxime axetil fda prescribing information, side.
Tablets are filmcoated and contain the equivalent of 250 mg or 500 mg of cefuroxime as cefuroxime axetil usp. Cefuroxime 250mg tablets summary of product characteristics. Cefuroxime axetil 250500mg bid to tid no dosage adjustments cephalexin 250500mg qid 250500mg tid to qid. Cefuroxime ceftin and zinacef side effects, dosage. Zinacef cefuroxime dose, indications, adverse effects. Dose adjustment may not be appropriate in acute renal impairment secondary to sepsis. Broadspectrum cephalosporin antibiotic resistant to betalactamase.
Cefuroxime axetil definition of cefuroxime axetil by. Cefuroxime axetil is an orally active prodrug of cefuroxime. Conversion to cefuroxime, the microbiologically active. In patients with markedly impaired renal function it is recommended that the dosage of cefuroxime should be reduced to compensate for its slower excretion. Contraindicationshypersensitivity to drug or class cautionpenicillin allergy, renal dysfunction, antibioticassociated colitis, seizure disorder, concomitant use of nephrotoxic drugs. Cefuroxime axetil, sold under the brand name zinnat among others, is a second generation oral cephalosporin antibiotic. In clinical trials using a single dose of cefuroxime axetil tablets, 1,061 patients were treated with the recommended dosage of cefuroxime axetil 1,000 mg for the treatment of uncomplicated gonorrhea. This prescription medication comes in the form of a tablet or oral suspension liquid and is typically taken twice daily.
Available as cefuroxime axetil or cefuroxime sodium. Abacavir abacavir lamivudine abacavir lamivudine zidovudine acarbose acebutolol acetaminophen acetazolamide acetohexamide acetohydroxamic acid acetylsalicylic acid aspirin acrivastine acyclovir adefovir adenosine albuterol inhaled albuterol oral alfentanil alfentanil allopurinol alprazolam alteplase tissuetype plasminogen activator. It has been proposed for infections with gramnegative and grampositive organisms, gonorrhea, and haemophilus. After oral administration, cefuroxime axetil, as ceftin, is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release cefuroxime into the blood stream. Cefuroxime axetil is an acetoxyethyl ester prodrug of cefuroxime which is effective when taken by mouth. Cefuroxime axetil suspension for reconstitution side effects by likelihood and severity common side effects. Administer ceftin tablets or oral suspension as described in the appropriate dosage guidelines see dosage and administration 2. Click precautions and warnings with cefuroxime axetil to learn more, including information on who should not take the drug. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. In patients with rapidly changing renal function i. The adverse reactions in table 6 were for subjects treated with a single dose of 1,000 mg cefuroxime axetil tablets in u. Tell your healthcare professional if you are taking any other. Cefuroxime kefstar vs axetil the doctor prescribed me 21 pcs of cefuroxime kefstar for 7 days, but i only purchased 9 pcs, and i substituted it for cefuroxime axetil. The amount prescribed will depend on several factors, such as the form of the medication used tablets or oral suspension, other medical conditions you may have, and age and weight.
Cefuroxime axetil is an acceptable alternative agent biii. Pharmacokinetics and tolerance of cefuroxime axetil in volunteers during repeated dosing. Use caution in patients with history of colitis, renal impairment, or with a history of seizure disorders. Common and rare side effects for cefuroxime axetil oral. Cefuroxime is a prescription drug available under the brand names ceftin and zinacef. The safety and efficacy of cefuroxime axetil in patients with renal failure have not been established. The adverse reactions in table 6 were for subjects treated with a single dose of 1,000 mg cefuroxime axetil in u. Cefuroxime axetil information, side effects, warnings and recalls.
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